The PROVENGE Difference

HowPROVENGE Targets and Attacks

PROVENGE activates T cells to target and attack prostate cancer cells.

Watch the mechanism of action

Immunotherapy Helps the Immune System Fight Disease

PROVENGE is an autologous cellular immunotherapy designed to activate a patient’s immune system to target and attack prostate cancer cells.

Learn more about PROVENGE as immunotherapy

ShortDuration of PROVENGE Therapy

PROVENGE therapy typically takes about 1 month, and a sustained immune response has been observed out to 26 weeks.

Read about the sustained response of PROVENGE

ManageableSide Effect Profile

Only 1.5% of patients in the pivotal Phase 3 IMPACT Trial discontinued treatment with PROVENGE due to adverse events.


The most common adverse events in PROVENGE trials were chills, fatigue, fever, back pain, nausea, joint ache, and headache.

Learn about safety & side effects of PROVENGE

Next : Mechanism Of Action

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IMPORTANT SAFETY INFORMATION
PROVENGE is intended solely for autologous use and is not routinely tested for transmissible infectious diseases.

In controlled clinical trials, serious adverse events reported in the PROVENGE group included acute infusion reactions (occurring within 1 day of infusion) and cerebrovascular events. Severe (Grade 3) acute infusion reactions were reported in 3.5% of patients in the PROVENGE group. Reactions included chills, fever, fatigue, asthenia, dyspnea, hypoxia, bronchospasm, dizziness, headache, hypertension, muscle ache, nausea, and vomiting. No Grade 4 or 5 acute infusion reactions were reported in patients in the PROVENGE group.

The most common adverse events (incidence ≥ 15%) reported in the PROVENGE group were chills, fatigue, fever, back pain, nausea, joint ache, and headache.

Please see the Full Prescribing Information.

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