Discover PROVENGE

PROVENGE Targets and Attacks

PROVENGE targets and attacks prostate cancer cells. Start early to activate the power of the immune system.

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PROVENGEProlongs Survival

PROVENGE, a first-line advanced prostate cancer treatment, delivers a statistically significant survival advantage by extending median overall survival beyond 2 years.1,2

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Short Therapy Duration and Sustained Immune Response*

PROVENGE has a short duration of therapy (approximately 1 month) and has demonstrated a sustained immune response, which was seen out to 26 weeks in the pivotal study (the last time point measured).1

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For Newly MetastaticCRPC Patients

PROVENGE is recommended by the NCCN as first-line treatment for asymptomatic or minimally symptomatic metastatic CRPC.3 Consider PROVENGE for patients:

  • With metastatic CRPC
  • Who are asymptomatic or minimally symptomatic
  • Who do not require narcotic analgesics for cancer-related pain

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*A sustained immune response was seen out to 26 weeks in the pivotal study (the last time point measured).1 Castrate-resistant prostate cancer
National Comprehensive Cancer Network

Prescribe PROVENGE

Become a PROVENGETreatment Center

Help your patients sustain* their fight against advanced prostate cancer by providing PROVENGE.

Comprehensive Support

Whether you want to become a treatment center or need help navigating the reimbursement and insurance benefits certification process, we’ve got you covered with a personal coordinator who can guide you throughout the prostate cancer treatment process.

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InfusingPROVENGE

Watch a video to learn how to infuse PROVENGE safely and appropriately.

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IntegratingPROVENGE

The PROVENGE Practice Pathway Resource Guide is an interactive reference source designed to help integrate PROVENGE therapy into your practice.

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This site is intended for US Health Care Professionals only.

INDICATION
PROVENGE® (sipuleucel-T) is an autologous cellular immunotherapy indicated for the treatment of asymptomatic or minimally symptomatic metastatic castrate-resistant (hormone-refractory) prostate cancer.

IMPORTANT SAFETY INFORMATION

Acute Infusion Reactions: Acute infusion reactions (reported within 1 day of infusion) may occur and include nausea, vomiting, fatigue, fever, rigor or chills, respiratory events (dyspnea, hypoxia, and bronchospasm), syncope, hypotension, hypertension, and tachycardia. Closely monitor patients with cardiac or pulmonary conditions.

Thromboembolic events: Thromboembolic events, including deep venous thrombosis and pulmonary embolism, can occur following infusion of PROVENGE. The clinical significance and causal relationship are uncertain. Most patients had multiple risk factors for these events. PROVENGE should be used with caution in patients with risk factors for thromboembolic events.

Vascular disorders: Cerebrovascular events (hemorrhagic/ischemic strokes and transient ischemic attacks) and cardiovascular disorders (myocardial infarctions) have been reported following infusion of PROVENGE. The clinical significance and causal relationship are uncertain. Most patients had multiple risk factors for these events.

Handling Precautions: PROVENGE is intended solely for autologous use and is not tested for transmissible infectious diseases.

Adverse Reactions: The most common adverse reactions reported in clinical trials (≥ 15% of patients receiving PROVENGE) were chills, fatigue, fever, back pain, nausea, joint ache, and headache.

Please see the Full Prescribing Information.

REFERENCES:
  1. PROVENGE [package insert]. Dendreon Corporation; October 2014.
  2. Kantoff PW, Higano CS, Shore ND, et al; for the IMPACT Study Investigators. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411-422.
  3. NCCN Clinical Practice Guidelines in Oncology: Prostate Cancer. V.2.2013. National Comprehensive Cancer Network Web site. www.nccn.org. Accessed May 21, 2013.